Group I metabotropic glutamate receptors control proliferation, survival and differentiation of cultured neural progenitor cells isolated from the subventricular zone of adult mice.

@article{Castiglione2008GroupIM,
  title={Group I metabotropic glutamate receptors control proliferation, survival and differentiation of cultured neural progenitor cells isolated from the subventricular zone of adult mice.},
  author={Marzia Castiglione and Marco Calafiore and Lara Costa and Maria Angela Sortino and Ferdinando Nicoletti and Agata G. Copani},
  journal={Neuropharmacology},
  year={2008},
  volume={55 4},
  pages={560-7}
}
Neural progenitor cells (NPCs) are found in the subventricular zone (SVZ) of the adult brain, a specialized neurogenic niche that might provide a substrate for brain repair after injury. The incomplete knowledge of how NPCs in the niche respond to local signals limits the use of cultured NPCs in the development of cell transplantation strategies. We show that neurospheres obtained from the SVZ of the adult mouse expressed functional mGlu1 and mGlu5 metabotropic glutamate receptors… CONTINUE READING

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