Group I intron renders differential susceptibility of Candida albicans to Bleomycin

@article{Jayaguru2006GroupII,
  title={Group I intron renders differential susceptibility of Candida albicans to Bleomycin},
  author={Prathiba Jayaguru and Malathi Raghunathan},
  journal={Molecular Biology Reports},
  year={2006},
  volume={34},
  pages={11-17}
}
The alarming increase in drug resistance gained by fungal pathogens has raised an urgent need to develop drugs against novel targets. Candida albicans, an opportunistic fungal pathogen, harbors in its 25S rRNA gene, a self-splicing Group I intron, which can act as a selective drug target. We report that Bleomycin selectively inhibits the self-splicing of Group I intron of C. albicans at IC50 = 1.2 μM, leading to accumulation of precursor RNA as evinced by Reverse Transcriptase PCR. Drug… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 11 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 30 REFERENCES