Group I PAK Inhibitor IPA-3 Induces Cell Death and Affects Cell Adhesivity to Fibronectin in Human Hematopoietic Cells

@inproceedings{Kuelov2014GroupIP,
  title={Group I PAK Inhibitor IPA-3 Induces Cell Death and Affects Cell Adhesivity to Fibronectin in Human Hematopoietic Cells},
  author={Kateřina Ku{\vz}elov{\'a} and Dana Grebeňov{\'a} and Ale{\vs} Holoubek and Pavla R{\"o}selov{\'a} and Adam Obr},
  booktitle={PloS one},
  year={2014}
}
P21-activated kinases (PAKs) are involved in the regulation of multiple processes including cell proliferation, adhesion and migration. However, the current knowledge about their function is mainly based on results obtained in adherent cell types. We investigated the effect of group I PAK inhibition using the compound IPA-3 in a variety of human leukemic cell lines (JURL-MK1, MOLM-7, K562, CML-T1, HL-60, Karpas-299, Jurkat, HEL) as well as in primary blood cells. IPA-3 induced cell death with… CONTINUE READING
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