Group I Metabotropic Glutamate Receptors: A Role in Neurodevelopmental Disorders?

@article{Catania2007GroupIM,
  title={Group I Metabotropic Glutamate Receptors: A Role in Neurodevelopmental Disorders?},
  author={M V Catania and Simona D’Antoni and Carmela Maria Bonaccorso and E. Aronica and Mark F. Bear and Ferdinando Nicoletti},
  journal={Molecular Neurobiology},
  year={2007},
  volume={35},
  pages={298-307}
}
Group I metabotropic glutamate receptors (mGlu1 and mGlu5) are coupled to polyphosphoinositide hydrolysis and are involved in activity-dependent forms of synaptic plasticity, both during development and in the adult life. Group I mGlu receptors can also regulate proliferation, differentiation, and survival of neural stem/progenitor cells, which further support their role in brain development. An exaggerated response to activation of mGlu5 receptors may underlie synaptic dysfunction in Fragile X… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 148 references

Similar Papers

Loading similar papers…