Group I Metabotropic Glutamate Receptor-mediated Gene Expression in Striatal Neurons

@article{Mao2008GroupIM,
  title={Group I Metabotropic Glutamate Receptor-mediated Gene Expression in Striatal Neurons},
  author={Li-min Mao and Guo-Chi Zhang and X Liu and Eugene E. Fibuch and John Q Wang},
  journal={Neurochemical Research},
  year={2008},
  volume={33},
  pages={1920-1924}
}
Group I mGluRs (mGluR1/5) are G-protein-coupled receptors and are abundantly expressed in most of medium spiny projection neurons in the striatum. Recent evidence demonstrates that group I mGluRs are among essential regulators for constitutive and inducible gene expression in host neurons. Upon activation, mGluR1/5 signals activate extracellular signal-regulated kinases (ERKs) which in turn phosphorylate transcription factors such as cAMP response element-binding protein (CREB) and Elk-1, and… CONTINUE READING
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Metabotropic glutamate receptor 5-regulated behaviors and immediate early gene expression in the striatum of normal and amphetamine-treated rats

  • NK Parelkar, JQ Wang
  • Mol Brain Res
  • 2004
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