Group D prothrombin activators from snake venom are structural homologues of mammalian blood coagulation factor Xa.

@article{Rao2003GroupDP,
  title={Group D prothrombin activators from snake venom are structural homologues of mammalian blood coagulation factor Xa.},
  author={V. Sambasiva Rao and Jeremiah S Joseph and R Manjunatha Kini},
  journal={The Biochemical journal},
  year={2003},
  volume={369 Pt 3},
  pages={635-42}
}
Procoagulant venoms of several Australian elapids contain proteinases that specifically activate prothrombin; among these, Group D activators are functionally similar to coagulation factor Xa (FXa). Structural information on this class of prothrombin activators will contribute significantly towards understanding the mechanism of FXa-mediated prothrombin activation. Here we present the purification of Group D prothrombin activators from three Australian snake venoms (Hoplocephalus stephensi… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

Detection of venom-antivenom (VAV) immunocomplexes in vitro as a measure of antivenom efficacy.

Toxicon : official journal of the International Society on Toxinology • 2014
View 1 Excerpt

In vivo evaluation of homeostatic effects of Echis carinatus snake venom in Iran

Journal of Venomous Animals and Toxins including Tropical Diseases • 2012
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 39 references

Similar Papers

Loading similar papers…