Group B streptococcal capsular sialic acids interact with siglecs (immunoglobulin-like lectins) on human leukocytes.

@article{Carlin2007GroupBS,
  title={Group B streptococcal capsular sialic acids interact with siglecs (immunoglobulin-like lectins) on human leukocytes.},
  author={Aaron F Carlin and Amanda L Lewis and Ajit Varki and Victor Nizet},
  journal={Journal of bacteriology},
  year={2007},
  volume={189 4},
  pages={
          1231-7
        }
}
Group B Streptococcus (GBS) is classified into nine serotypes that vary in capsular polysaccharide (CPS) architecture but share in common the presence of a terminal sialic acid (Sia) residue. This position and linkage of GBS Sia closely resembles that of cell surface glycans found abundantly on human cells. CD33-related Siglecs (CD33rSiglecs) are a family of Sia-binding lectins expressed on host leukocytes that engage host Sia-capped glycans and send signals that dampen inflammatory gene… CONTINUE READING

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