Group B Streptococcus pilus sortase regulation: a single mutation in the lid region induces pilin protein polymerization in vitro.

@article{Cozzi2013GroupBS,
  title={Group B Streptococcus pilus sortase regulation: a single mutation in the lid region induces pilin protein polymerization in vitro.},
  author={Roberta Cozzi and Francesca Zerbini and Michael Assfalg and Mariapina D'Onofrio and Massimiliano Biagini and Manuele Martinelli and Annalisa Nuccitelli and Nathalie Norais and John L. Telford and Domenico Maione and C. Daniela Rinaudo},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2013},
  volume={27 8},
  pages={3144-54}
}
Gram-positive bacteria build pili on their cell surface via a class C sortase-catalyzed transpeptidation mechanism from pilin protein substrates. Despite the availability of several crystal structures, pilus-related C sortases remain poorly characterized to date, and their mechanisms of transpeptidation and regulation need to be further investigated. The available 3-dimensional structures of these enzymes reveal a typical sortase fold, except for the presence of a unique feature represented by… CONTINUE READING

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