In addition to sparking the first ever U.S. government health warning for travel within the continental United States, the 2016 Zika virus (ZIKV) outbreak was notable for the geographical resolution with which the three Ground Zero areas were specified, i.e. Wynwood (Fig. 1a), Miami Beach and Little River which are all separated from each other by a short drive within the Miami area. Grubaugh et al.  provide a remarkable analysis of ZIKV genomes from infected patients and Aedes aegypti mosquitoes, and conclude that multiple introductions of the virus contributed to this 2016 outbreak in Florida; that local transmission likely started several months before its initial detection; and that ZIKV moved among transmission zones in Miami.