Groucho oligomerization is required for repression in vivo.

  title={Groucho oligomerization is required for repression in vivo.},
  author={Haiyun Song and Peleg Hasson and Ze'ev Paroush and Albert J. Courey},
  journal={Molecular and cellular biology},
  volume={24 10},
Drosophila Groucho (Gro) is a member of a family of metazoan corepressors with widespread roles in development. Previous studies indicated that a conserved domain in Gro, termed the Q domain, was required for repression in cultured cells and mediated homotetramerization. Evidence presented here suggests that the Q domain contains two coiled-coil motifs required for oligomerization and repression in vivo. Mutagenesis of the putative hydrophobic faces of these motifs, but not of the hydrophilic… CONTINUE READING

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