Groucho oligomerization is required for repression in vivo.

@article{Song2004GrouchoOI,
  title={Groucho oligomerization is required for repression in vivo.},
  author={Haiyun Song and Peleg Hasson and Ze'ev Paroush and Albert J. Courey},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 10},
  pages={4341-50}
}
Drosophila Groucho (Gro) is a member of a family of metazoan corepressors with widespread roles in development. Previous studies indicated that a conserved domain in Gro, termed the Q domain, was required for repression in cultured cells and mediated homotetramerization. Evidence presented here suggests that the Q domain contains two coiled-coil motifs required for oligomerization and repression in vivo. Mutagenesis of the putative hydrophobic faces of these motifs, but not of the hydrophilic… CONTINUE READING

From This Paper

Topics from this paper.
35 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

Similar Papers

Loading similar papers…