Grossularine-1 and grossularine-2, cytotoxic α-carbolines from the tunicate: Dendrodoa grossularia

@article{MoquinPattey1989Grossularine1AG,
  title={Grossularine-1 and grossularine-2, cytotoxic $\alpha$-carbolines from the tunicate: Dendrodoa grossularia},
  author={C. Moquin-Pattey and M. Guyot},
  journal={Tetrahedron},
  year={1989},
  volume={45},
  pages={3445-3450}
}
Abstract Several indole derivatives were isolated from the tunicate: Dendrodoa grossularia among which two α-carbolines: grossularine-1 (revised structure) and grossularine-2. The structures were based upon spectral data, including X-ray analysis for grossularine-2. These compounds exhibit marked cytotoxicity toward murine and human tumor cells. They are the first example of naturally occurring α-carbolines. 
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Results of viscometry, fluorescence quenching and DNA melting experiments clearly indicated the intercalative properties of grossularine-2 explained by its quasi-planar structure and the non-intercalative DNA binding of grossularityine-1 explained by the presence of a bulky indole chain at the 2-position of the alpha-carboline ring. Expand
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