Gross defects in the vpr and vpu genes of HIV type 1 cannot explain the differences in RNA copy number between long-term asymptomatics and progressors.

@article{Cornelissen1997GrossDI,
  title={Gross defects in the vpr and vpu genes of HIV type 1 cannot explain the differences in RNA copy number between long-term asymptomatics and progressors.},
  author={Marion Cornelissen and Carla L. Kuiken and Fokla Zorgdrager and Stephen Hartman and Jaap Goudsmit},
  journal={AIDS research and human retroviruses},
  year={1997},
  volume={13 3},
  pages={247-52}
}
Disease progression in HIV-1-infected individuals is strongly associated with persistent and high numbers of HIV-1 RNA copies. We previously reported a markedly lower viral RNA load in eight long-term asymptomatics (LTAs) compared to seven matched progressors (at 1 year after seroconversion or entry in the study, p < 0.001) (Hogervorst E, et al.: J Infect Dis 1995;171:811-821). Here we extend our study to examine whether a difference in viral load can be attributed to infection by viruses… CONTINUE READING