Griseusin D, a New Pyranonaphthoquinone Derivative from a Alkaphilic Nocardiopsis sp.

@article{Li2007GriseusinDA,
  title={Griseusin D, a New Pyranonaphthoquinone Derivative from a Alkaphilic Nocardiopsis sp.},
  author={Y. Li and M. Li and Wei Li and Jiang-yuan Zhao and Zhang-Gui Ding and Xiaolong Cui and Meng-liang Wen},
  journal={The Journal of Antibiotics},
  year={2007},
  volume={60},
  pages={757-761}
}
A new pyranonaphthoquinone antibiotic, griseusin D (1) was isolated from the cultural fluid of the alkaphilic Nocardiopsis sp. The structure was determined as 5′-one-4-hydroxy-12-methoxygriseusin by spectroscopic methods, comparison with reported data and single-crystal X-ray analysis. 1 displayed strong cytotoxicity against human leukemia cells (HL60) and modest cytotoxicity against human lung adenocarcinoma cell lines (AGZY) with IC50 values of 0.23 and 19.6 μg/ml, respectively. It also… Expand
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