Griseofulvin potentiates antitumorigenesis effects of nocodazole through induction of apoptosis and G2/M cell cycle arrest in human colorectal cancer cells.

@article{Ho2000GriseofulvinPA,
  title={Griseofulvin potentiates antitumorigenesis effects of nocodazole through induction of apoptosis and G2/M cell cycle arrest in human colorectal cancer cells.},
  author={Y. Ho and J. Duh and J. Jeng and Y. Wang and Y. Liang and C. H. Lin and C. Tseng and C. F. Yu and R. J. Chen and J. Lin},
  journal={International journal of cancer},
  year={2000},
  volume={91 3},
  pages={
          393-401
        }
}
  • Y. Ho, J. Duh, +7 authors J. Lin
  • Published 2000
  • Biology, Medicine
  • International journal of cancer
In this study, we demonstrate that apoptosis and G2/M cell cycle arrest were easily induced by treatment with the oral-antifungal agent, griseofulvin (GF). The mechanisms of GF-induced G2/M arrest were characterized as (a) induction of abnormal mitotic spindle formation, (b) elevation of cyclin B1/cdc2 kinase activity and (c) down-regulation of myt-1 protein expression. On the other hand, caspase 3 activation, Bcl-2 hyperphosphorylation and inhibition of the normal function of Bcl-2 associated… Expand
Microtubule assembly dynamics: An attractive target for anticancer drugs
Antitumor effects of miconazole on human colon carcinoma xenografts in nude mice through induction of apoptosis and G0/G1 cell cycle arrest.
  • C. Wu, J. Jeng, +9 authors Y. Ho
  • Biology, Medicine
  • Toxicology and applied pharmacology
  • 2002
Involvement of proapoptotic Bcl-2 family members in terbinafine-induced mitochondrial dysfunction and apoptosis in HL60 cells.
  • Kuo-ching Yang, Chi-Chen Wu, +10 authors Y. Ho
  • Biology, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2006
...
1
2
3
4
5
...