Grisemycin, a Bridged Angucyclinone with a Methylsulfinyl Moiety from a Marine-Derived Streptomyces sp.

@article{Xie2016GrisemycinAB,
  title={Grisemycin, a Bridged Angucyclinone with a Methylsulfinyl Moiety from a Marine-Derived Streptomyces sp.},
  author={Zeping Xie and L Zhou and Lin Guo and Xiaoping Yang and Guiwu Qu and Changjing Wu and Shiying Zhang},
  journal={Organic letters},
  year={2016},
  volume={18 6},
  pages={1402-5}
}
Grisemycin (1), the first sulfur angucyclinone with an unusual ether-bridged system, was isolated from a marine-derived Streptomyces griseus strain M268. Its novel, here cage-like, structure was determined by spectroscopic analysis and single-crystal X-ray diffraction. Compound 1 exhibited modestly selective activity against the HL-60 cell line with an IC50 value of 31.54 μM. Futhermore, the absolute stereochemistry of kiamycin (2), an 1,12-epoxybenz[a]anthracene, previously obtained from the… CONTINUE READING
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