Grip and slip of L1-CAM on adhesive substrates direct growth cone haptotaxis

Abstract

Chemical cues presented on the adhesive substrate direct cell migration, a process termed haptotaxis. To migrate, cells must generate traction forces upon the substrate. However, how cells probe substrate-bound cues and generate directional forces for migration remains unclear. Here, we show that the cell adhesion molecule (CAM) L1-CAM is involved in… (More)
DOI: 10.1073/pnas.1711667115

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