Grifolin inhibits tumor cells adhesion and migration via suppressing interplay between PGC1α and Fra-1/LSF-MMP2/CD44 axes

@inproceedings{Luo2016GrifolinIT,
  title={Grifolin inhibits tumor cells adhesion and migration via suppressing interplay between PGC1α and Fra-1/LSF-MMP2/CD44 axes},
  author={Xiangjian Luo and Namei Li and Juanfang Zhong and Zheqiong Tan and Ying Liu and Xin Dong and Can Cheng and Zhijie Xu and Hongde Li and Lifang Yang and M. -J. Tang and Xinxian Weng and Wei Yi and Jikai Liu and Ya Cao},
  booktitle={Oncotarget},
  year={2016}
}
Grifolin, a farnesyl phenolic compound isolated from the fresh fruiting bodies of the mushroom Albatrellus confluens, exhibits effective antitumor bioactivity in previous study of our group and other lab. In this study, we observed that grifolin inhibited tumor cells adhesion and migration. Moreover, grifolin reduced reactive oxygen species (ROS) production and caused cellular ATP depletion in high-metastatic tumor cells. PGC1α (Peroxisome proliferator-activated receptor γ, coactivator 1… CONTINUE READING