Grifolin directly targets ERK1/2 to epigenetically suppress cancer cell metastasis

@inproceedings{Luo2015GrifolinDT,
  title={Grifolin directly targets ERK1/2 to epigenetically suppress cancer cell metastasis},
  author={Xiangjian Luo and Lifang Yang and Lanbo Xiao and Xiaofeng Xia and Xin Dong and Juanfang Zhong and Ying Liu and Namei Li and Ling Chen and Hongde Li and Wei Li and Wenbin Liu and Xinfang Yu and Hanyong Chen and M. -J. Tang and Xinxian Weng and Wei Yi and Ann M. Bode and Zigang Dong and Jikai Liu and Ya Cao},
  booktitle={Oncotarget},
  year={2015}
}
Grifolin, a secondary metabolite isolated from the fresh fruiting bodies of the mushroom Albatrellus confluens, has been reported by us and others to display potent antitumor effects. However, the molecular target of grifolin has not been identified and the underlying mechanism of action is not fully understood. Here, we report that the ERK1/2 protein kinases are direct molecular targets of grifolin. Molecular modeling, affinity chromatography and fluorescence quenching analyses showed that… CONTINUE READING
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