Gridlock signalling pathway fashions the first embryonic artery

  title={Gridlock signalling pathway fashions the first embryonic artery},
  author={Tao P. Zhong and S. Terry Childs and James P. Leu and Mark C Fishman},
Arteries and veins are morphologically, functionally and molecularly very different, but how this distinction is established during vasculogenesis is unknown. Here we show, by lineage tracking in zebrafish embryos, that angioblast precursors for the trunk artery and vein are spatially mixed in the lateral posterior mesoderm. Progeny of each angioblast, however, are restricted to one of the vessels. This arterial–venous decision is guided by gridlock (grl), an artery-restricted gene that is… CONTINUE READING
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