Gridline: automatic grid alignment DNA microarray scans

@article{Bajcsy2004GridlineAG,
  title={Gridline: automatic grid alignment DNA microarray scans},
  author={Peter Bajcsy},
  journal={IEEE Transactions on Image Processing},
  year={2004},
  volume={13},
  pages={15-25}
}
We present a new automatic grid alignment algorithm for detecting two-dimensional (2-D) arrays of spots in DNA microarray images. Our motivation for this work is the lack of automation in high-throughput microarray data analysis that leads to a) spatial inaccuracy of located spots and hence inaccuracy of extracted information from a spot and b) inconsistency of extracted features due to manual selection of grid alignment parameters. The proposed grid alignment algorithm is novel in the sense… CONTINUE READING
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