Grid cells in pre- and parasubiculum

@article{Boccara2010GridCI,
  title={Grid cells in pre- and parasubiculum},
  author={Charlotte N. Boccara and Francesca Sargolini and Veslem{\o}y Hult Thoresen and Trygve Solstad and Menno P. Witter and Edvard I. Moser and May-Britt Moser},
  journal={Nature Neuroscience},
  year={2010},
  volume={13},
  pages={987-994}
}
Allocentric space is mapped by a widespread brain circuit of functionally specialized cell types located in interconnected subregions of the hippocampal-parahippocampal cortices. [] Key Result The proportion of grid cells in pre- and parasubiculum was comparable to deep layers of MEC. The symmetry of the grid pattern and its relationship to the theta rhythm were weaker, especially in presubiculum. Pre- and parasubicular grid cells intermingled with head-direction cells and border cells, as in deep MEC layers…

Figures from this paper

Local microcircuitry of parasubiculum shows distinct and common features of excitatory and inhibitory connectivity
TLDR
The microcircuit that is uncovered shares both similarities and divergences to those from other parahippocampal regions also involved in spatial navigation, as well as features of pyramid to pyramid interactions indicative of a non-random network.
Functional network topography of the medial entorhinal cortex
TLDR
The topographic arrangement of spatially modulated neurons in MEC and adjacent parasubiculum is examined using miniaturized, portable two-photon microscopes, which allow mice to roam freely in open fields and suggest that grid-cell networks might be largely distinct from those of border, HD and OV cells and that grid cells exhibit strong coupling among themselves but weaker links to other cell types.
Local Microcircuitry of PaS Shows Distinct and Common Features of Excitatory and Inhibitory Connectivity
TLDR
High rates of interconnectivity between the pyramidal class and interneurons, as well as features of pyramid-to-pyramid interactions indicative of a nonrandom network are found.
Functional network topography of the medial entorhinal cortex
TLDR
Miniaturized, portable two-photon microscopes are used to image grid, head-direction, border, as well as object-vector cells in MEC and neighboring parasubiculum within the same animals to suggest grid cell networks might be largely distinct from those of border, HD, and OV cells and that grid cells exhibit strong coupling among themselves but weaker links to other cell types.
Excitatory Microcircuits within Superficial Layers of the Medial Entorhinal Cortex.
Microcircuits for spatial coding in the medial entorhinal cortex
TLDR
Recent investigations of intrinsic MEC connectivity have started to describe and quantify both excitatory and inhibitory wiring in the superficial layers of the MEC, and it appears that these layers contain robust recurrent connectivity that could sustain the attractor dynamics posited to underlie grid-pattern formation.
Entorhinal fast-spiking speed cells project to the hippocampus
TLDR
It is shown that a large proportion of entorhinal speed cells are fast-spiking with properties similar to those of GABAergic interneurons and that outputs from a subset of these cells, particularly the parvalbumin-expressing subset, form a component of the medial entorHinal input to the hippocampus.
Functional connectivity of the entorhinal–hippocampal space circuit
TLDR
An optogenetic strategy to identify functionally defined cell types in the MEC that project directly to the hippocampus is developed, and photoexcitation experiments can be used to distinguish the subset of hippocampus-projecting entorhinal neurons from neurons that are activated indirectly through the network.
Head-Directional Tuning and Theta Modulation of Anatomically Identified Neurons in the Presubiculum
TLDR
It is shown that HD cells in the presubiculum are pyramidal cells, with FS interneurons only showing weak HD tuning; therefore, MEC may receive an excitatory HD input, as previously assumed by many models.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 58 REFERENCES
Place cells recorded in the parasubiculum of freely moving rats
TLDR
This study conducted single unit recordings in the parasubiculum of freely moving rats trained to retrieve food pellets thrown randomly into a cylindrical apparatus to determine the types of behavioral and spatial correlates in neurons from the PaS.
Cohesiveness of spatial and directional representations recorded from neural ensembles in the anterior thalamus, parasubiculum, medial entorhinal cortex, and hippocampus
TLDR
The parahippocampal and MEC input to the hippocampus can be controlled by the animal's internal direction sense and become completely decoupled from external sensory input, yet maintain internal coherence with each other and in general with the place cell system of the hippocampus.
Development of the Hippocampal Cognitive Map in Preweanling Rats
TLDR
The results demonstrate the presence of three neuronal representations of space before extensive experience and show how they develop with age, providing experimental support for Kant's 200-year-old concept of space as an a priori faculty of the mind.
Place cells, grid cells, and the brain's spatial representation system.
TLDR
How place cells and grid cells may form the basis for quantitative spatiotemporal representation of places, routes, and associated experiences during behavior and in memory is reviewed.
Hippocampus-independent phase precession in entorhinal grid cells
TLDR
It is shown that phase precession is expressed independently of the hippocampus in spatially modulated grid cells in layer II of medial entorhinal cortex, one synapse upstream of the amygdala, raising the possibility that hippocampal phasePrecession is inherited from entorHinal cortex.
Hippocampal remapping and grid realignment in entorhinal cortex
TLDR
The nature of hippocampal remapping can be predicted by ensemble dynamics in place-selective grid cells in the medial entorhinal cortex, one synapse upstream of the hippocampus, and is shown to be associated with stable grid fields.
Microstructure of a spatial map in the entorhinal cortex
TLDR
The dorsocaudal medial entorhinal cortex (dMEC) contains a directionally oriented, topographically organized neural map of the spatial environment, whose key unit is the ‘grid cell’, which is activated whenever the animal's position coincides with any vertex of a regular grid of equilateral triangles spanning the surface of the environment.
Influence of boundary removal on the spatial representations of the medial entorhinal cortex
TLDR
Results show that manipulation of local boundaries can exert a powerful influence on the spatial firing patterns of MEC cells even when the manipulations leave global cues unchanged and allow uninterrupted, self‐motion‐based localization, and suggest the presence of landmark‐related information in MEC, which might prevent cumulative drift of the spatial representation or might reset it to a previously learned configuration in a familiar environment.
Local generation of theta-frequency EEG activity in the parasubiculum.
TLDR
Results indicate that theta field activity is generated locally within the parasubiculum and that intrinsic membrane potential oscillations, synchronized by local inhibitory inputs, may contribute to the generation of this activity.
Representation of Geometric Borders in the Entorhinal Cortex
TLDR
The existence of an entorhinal cell type that fires when an animal is close to the borders of the proximal environment is reported, and border cells may be instrumental in planning trajectories and anchoring grid fields and place fields to a geometric reference frame.
...
1
2
3
4
5
...