Grey matter alterations in patients with Pantothenate Kinase-Associated Neurodegeneration (PKAN).

@article{RodriguezRaecke2014GreyMA,
  title={Grey matter alterations in patients with Pantothenate Kinase-Associated Neurodegeneration (PKAN).},
  author={R Rodriguez-Raecke and Pedro Roa-Sanchez and Herwin Speckter and Rafael O Ferm{\'i}n-Delgado and Eddy N P{\'e}rez-Then and Jorge Omar Hern{\'a}ndez Oviedo and Peter Stoeter},
  journal={Parkinsonism & related disorders},
  year={2014},
  volume={20 9},
  pages={
          975-9
        }
}
BACKGROUND Pantothenate Kinase-Associated Neurodegeneration (PKAN) is a rare heritable disease marked by dystonia and loss of movement control. In contrast to the well-known "Eye-of-the-Tiger" sign affecting the globus pallidus, little is known about other deviations of brain morphology, especially about grey matter changes. METHODS We investigated 29 patients with PKAN and 29 age-matched healthy controls using Magnet Resonance Imaging and Voxel-Based Morphometry. RESULTS As compared to… CONTINUE READING
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