Green tea polyphenols block endotoxin-induced tumor necrosis factor-production and lethality in a murine model.

@article{Yang1998GreenTP,
  title={Green tea polyphenols block endotoxin-induced tumor necrosis factor-production and lethality in a murine model.},
  author={F. Yang and Willem JS de Villiers and Craig J. McClain and Gary W. Varilek},
  journal={The Journal of nutrition},
  year={1998},
  volume={128 12},
  pages={
          2334-40
        }
}
Green tea polyphenols are potent antioxidants. They have both anti-cancer and anti-inflammatory effects. However, their mechanisms of actions remain unclear. In inflammation, tumor necrosis factor-alpha(TNFalpha) plays a pivotal role. NF-KB, an oxidative stress -sensitive nuclear transcription factor, controls the expression of many genes including the TNFalpha gene. We postulated that green tea polyphenols regulate TNFalpha gene expression by modulating NF-KB activation through their… 

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