Corpus ID: 89033514

Green tea polyphenols are associated with changes in genetic and epigenetic anti-cancer mechanisms in vitro and in vivo

@inproceedings{Berletch2007GreenTP,
  title={Green tea polyphenols are associated with changes in genetic and epigenetic anti-cancer mechanisms in vitro and in vivo},
  author={Joel B. Berletch},
  year={2007}
}
Human chromosomes are protected from degradation associated with cell division by hexameric repeats of 5’-TTAGGG-3’ termed telomeres. During cellular replication human chromosomes undergo the loss of up to 300 bp of DNA with each division, reaching a critical length which leads to senescence and apoptosis. Most cancer cells bypass this lifespan regulatory mechanism by the expression of telomerase, a protein complex that adds telomeres through the reverse transcriptase activity of its catalytic… Expand

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