Green tea polyphenol epigallocatechin-3-gallate inhibits the endothelin axis and downstream signaling pathways in ovarian carcinoma.

@article{Spinella2006GreenTP,
  title={Green tea polyphenol epigallocatechin-3-gallate inhibits the endothelin axis and downstream signaling pathways in ovarian carcinoma.},
  author={Francesca M. Spinella and Laura Rosan{\`o} and Valeriana Di Castro and Samantha Decandia and Adriana Maia Albini and Maria Rita Nicotra and Pier Giorgio Natali and Anna Bagnato},
  journal={Molecular cancer therapeutics},
  year={2006},
  volume={5 6},
  pages={
          1483-92
        }
}
The polyphenol epigallocatechin-3-gallate (EGCG), the principal mediator of the green tea, has been known to possess antitumor effect. The endothelin A receptor (ET(A)R)/endothelin-1 (ET-1) axis is overexpressed in ovarian carcinoma representing a novel therapeutic target. In this study, we examined the green tea and EGCG effects on two ovarian carcinoma cell lines, HEY and OVCA 433. EGCG inhibited ovarian cancer cell growth and induced apoptosis that was associated with a decrease in Bcl-X(L… CONTINUE READING

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