Green tea polyphenol EGCG sensitizes human prostate carcinoma LNCaP cells to TRAIL-mediated apoptosis and synergistically inhibits biomarkers associated with angiogenesis and metastasis

@article{Siddiqui2008GreenTP,
  title={Green tea polyphenol EGCG sensitizes human prostate carcinoma LNCaP cells to TRAIL-mediated apoptosis and synergistically inhibits biomarkers associated with angiogenesis and metastasis},
  author={Imtiaz Ahmad Siddiqui and Arshi Malik and Vaqar Mustafa Adhami and Mohammad Asim and Bilal Bin Hafeez and Sami Sarfaraz and Hasan Mukhtar},
  journal={Oncogene},
  year={2008},
  volume={27},
  pages={2055-2063}
}
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL/Apo2L) is a promising candidate for cancer therapy, however, emergence of drug resistance limits its potential use. Here, we report for the first time that epigallocatechin-3-gallate (EGCG), the major polyphenolic constituent of green tea, sensitizes TRAIL-resistant LNCaP cells to TRAIL-mediated apoptosis through modulation of intrinsic and extrinsic apoptotic pathways. When combined with EGCG, Apo2L/TRAIL exhibited enhanced… CONTINUE READING