Green tea extract increases cyclophosphamide-induced teratogenesis by modulating the expression of cytochrome P-450 mRNA.

@article{Park2009GreenTE,
  title={Green tea extract increases cyclophosphamide-induced teratogenesis by modulating the expression of cytochrome P-450 mRNA.},
  author={DongSun Park and Jeong Hee Jeon and Sunhee Shin and Seong Soo Joo and Dae-Hyuck Kang and Seol-Hee Moon and Min-Jung Jang and Yeoung Mi Cho and Jae Wook Kim and Hyeong-Jin Ji and Byeongwoo Ahn and Ki-Wan Oh and Yun-Bae Kim},
  journal={Reproductive toxicology},
  year={2009},
  volume={27 1},
  pages={79-84}
}
The effects of green tea extract (GTE) on the fetal development and external, visceral and skeletal abnormalities induced by cyclophosphamide were investigated in rats. Pregnant rats were daily administered GTE (100mg/kg) by gavage for 7 d, from the 6th to 12th day of gestation, and intraperitoneally administered with cyclophosphamide (11mg/kg) 1h after the final treatment. On the 20th day of gestation, maternal and fetal abnormalities were determined by Cesarian section. Cyclophosphamide was… CONTINUE READING

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