Green tea epigallocatechin-3-gallate mediates T cellular NF-kappa B inhibition and exerts neuroprotection in autoimmune encephalomyelitis.

@article{Aktas2004GreenTE,
  title={Green tea epigallocatechin-3-gallate mediates T cellular NF-kappa B inhibition and exerts neuroprotection in autoimmune encephalomyelitis.},
  author={Orhan Aktas and Timour Prozorovski and Alina Smorodchenko and Nicolai Savaskan and Roland Lauster and Peter M Kloetzel and Carmen Infante-Duarte and Stefan Brocke and Frauke Zipp},
  journal={Journal of immunology},
  year={2004},
  volume={173 9},
  pages={5794-800}
}
Recent studies in multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE), point to the fact that even in the early phase of inflammation, neuronal pathology plays a pivotal role in the sustained disability of affected individuals. We show that the major green tea constituent, (-)-epigallocatechin-3-gallate (EGCG), dramatically suppresses EAE induced by proteolipid protein 139-151. EGCG reduced clinical severity when given at initiation or after the onset of EAE… CONTINUE READING

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