Green tea epigallocatechin-3-gallate is an inhibitor of mammalian histidine decarboxylase

  title={Green tea epigallocatechin-3-gallate is an inhibitor of mammalian histidine decarboxylase},
  author={Carlos Rodr{\'i}guez-Caso and Daniel Rodr{\'i}guez-Agudo and Francisca S{\'a}nchez-Jim{\'e}nez and Miguel {\'A}ngel Medina},
  journal={Cellular and Molecular Life Sciences CMLS},
(–)-Epigallocatechin-3-gallate, an antiproliferative and antiangiogenic component of green tea, has been reported to inhibit dopa decarboxylase. In this report, we show that this compound also inhibits histidine decarboxylase, the enzymic activity responsible for histamine biosynthesis. This inhibition was proved by a double approach, activity measurements and UV-Vis spectra of enzyme-bound pyridoxal-5′-phosphate. At 0.1mM (–)-epigallocatechin-3-gallate, histidine decarboxylase activity was… CONTINUE READING


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