Green or red: what stops the traffic in the tetrapyrrole pathway?

  title={Green or red: what stops the traffic in the tetrapyrrole pathway?},
  author={Johanna E. Cornah and Matthew J Terry and Alison G Smith},
  journal={Trends in plant science},
  volume={8 5},
Regulation of tetrapyrrole biosynthesis is crucial to plant metabolism. The two pivotal control points are formation of the initial precursor, 5-aminolaevulinic acid (ALA), and the metal-ion insertion step: chelation of Fe(2+) into protoporphyrin IX leads to haem and phytochromobilin, whereas insertion of Mg(2+) is the first step to chlorophyll. Recent studies with mutants and transgenic plants have demonstrated that perturbation of the branch point affects ALA formation. Moreover, one of the… CONTINUE READING

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