Green and Facile Assembly of Diverse Fused N-Heterocycles Using Gold-Catalyzed Cascade Reactions in Water

@article{Jia2019GreenAF,
  title={Green and Facile Assembly of Diverse Fused N-Heterocycles Using Gold-Catalyzed Cascade Reactions in Water},
  author={X. Jia and Pinyi Li and X. Liu and Jiafu Lin and Y. Chu and Jinhai Yu and Jiang Wang and H. Liu and F. Zhao},
  journal={Molecules},
  year={2019},
  volume={24}
}
  • X. Jia, Pinyi Li, +6 authors F. Zhao
  • Published 2019
  • Chemistry, Medicine
  • Molecules
  • The present study describes an AuPPh3Cl/AgSbF6-catalyzed cascade reaction between amine nucleophiles and alkynoic acids in water. This process proceeds in high step economy with water as the sole coproduct, and leads to the generation of two rings, together with the formation of three new bonds in a single operation. This green cascade process exhibits valuable features such as low catalyst loading, good to excellent yields, high efficiency in bond formation, excellent selectivity, great… CONTINUE READING
    3 Citations

    References

    SHOWING 1-10 OF 72 REFERENCES
    Gold-catalyzed tandem reaction in water: an efficient and convenient synthesis of fused polycyclic indoles
    • 37
    • PDF
    A Au(i)-catalyzed N-acyl iminium ion cyclization cascade.
    • 97