Green Tea Polyphenols Stimulate Mitochondrial Biogenesis and Improve Renal Function after Chronic Cyclosporin A Treatment in Rats

@inproceedings{Rehman2013GreenTP,
  title={Green Tea Polyphenols Stimulate Mitochondrial Biogenesis and Improve Renal Function after Chronic Cyclosporin A Treatment in Rats},
  author={Hasibur Rehman and Yasodha Krishnasamy and Khujista D Haque and Ronald G. Thurman and John J. Lemasters and Rick G Schnellmann and Zhi Zhong},
  booktitle={PloS one},
  year={2013}
}

• Hasibur Rehman, Yasodha Krishnasamy, +4 authors Zhi Zhong
• Published 2013 in PloS one
• DOI:10.1371/journal.pone.0065029

Our previous studies showed that an extract from Camellia sinenesis (green tea), which contains several polyphenols, attenuates nephrotoxicity caused by cyclosporine A (CsA). Since polyphenols are stimulators of mitochondrial biogenesis (MB), this study investigated whether stimulation of MB plays a role in green tea polyphenol protection against CsA renal toxicity. Rats were fed a powdered diet containing green tea polyphenolic extract (0.1%) starting 3 days prior to CsA treatment (25 mg/kg, i… CONTINUE READING

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