Greatwall kinase : a nuclear protein required for proper chromosome condensation and mitotic progression in Drosophila

@inproceedings{Yu2004GreatwallK,
  title={Greatwall kinase : a nuclear protein required for proper chromosome condensation and mitotic progression in Drosophila},
  author={Jiangtao Yu and Shawna L. Fleming and Byron Williams and Erika V. Williams and Zexiao Li and Patrizia Somma and Conly L. Rieder and Michael L Goldberg},
  year={2004}
}
utations in the Drosophila gene greatwall cause improper chromosome condensation and delay cell cycle progression in larval neuroblasts. Chromosomes are highly undercondensed, particularly in the euchromatin, but nevertheless contain phosphorylated histone H3, condensin, and topoisomerase II. Cells take much longer to transit the period of chromosome condensation from late G 2 through nuclear envelope breakdown. Mutant cells are also subsequently delayed at metaphase, M due to spindle… CONTINUE READING