Greatly increased autoantibody production in myasthenia gravis by thymocyte suspensions prepared with proteolytic enzymes.

@article{Willcox1983GreatlyIA,
  title={Greatly increased autoantibody production in myasthenia gravis by thymocyte suspensions prepared with proteolytic enzymes.},
  author={H. N. A. Willcox and John Newsom-Davis and Lesley Calder},
  journal={Clinical and experimental immunology},
  year={1983},
  volume={54 2},
  pages={378-86}
}
We have previously reported that cell suspensions prepared by mechanical dispersion of thymic tissue from myasthenia gravis (MG) patients spontaneously synthesise anti-acetyl-choline receptor autoantibodies (anti-AChR) in culture in many cases. We now find a 2-200-fold greater anti-AChR production if the cell suspensions are prepared with the proteolytic enzymes collagenase and dispase (THYC + D). This difference has been seen in seven of the first 10 cases tested. Using these enzymes, we now… CONTINUE READING
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