Greatly improved neurological outcome after spinal cord compression injury in AQP4-deficient mice.

@article{Saadoun2008GreatlyIN,
  title={Greatly improved neurological outcome after spinal cord compression injury in AQP4-deficient mice.},
  author={Samira Saadoun and B. A. Bell and Alan S Verkman and Marios C Papadopoulos},
  journal={Brain : a journal of neurology},
  year={2008},
  volume={131 Pt 4},
  pages={1087-98}
}
Aquaporin-4 (AQP4) is a water channel protein expressed in astrocytes throughout the CNS. In brain, AQP4 facilitates water balance and glial scar formation, which are important determinants of outcome after injury. Here, we provide evidence for AQP4-dependent spinal cord swelling following compression injury, resulting in remarkably improved outcome in AQP4-null mice. Two days after transient T6 spinal cord compression injury, wild-type mice developed more severe hindlimb weakness than AQP4… CONTINUE READING
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