• Corpus ID: 19649918

Greater oxidative susceptibility of the surface monolayer in small dense LDL may contribute to differences in copper-induced oxidation among LDL density subfractions.

@article{Tribble1995GreaterOS,
  title={Greater oxidative susceptibility of the surface monolayer in small dense LDL may contribute to differences in copper-induced oxidation among LDL density subfractions.},
  author={Diane L. Tribble and Ronald M. Krauss and Maarten G. Lansberg and P M Thiel and J J van den Berg},
  journal={Journal of lipid research},
  year={1995},
  volume={36 4},
  pages={
          662-71
        }
}
We monitored peroxidative stress in the surface monolayer as compared with the outer core of large, buoyant (d 1.025-1.032 g/ml) and small, dense (d 1.040-1.054 g/ml) low density lipoprotein (LDL) subfractions using the oxidation-labile fluorescent probes parinaric acid (PnA) and parinaric acid methyl ester (PnME), which partition preferentially into these respective regions of LDL. Oxidation was initiated either with CuSO4 (5 microM) or the iron (Fe3+)-containing lipophilic complex hemin (1.0… 
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References

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TLDR
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TLDR
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TLDR
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