Greater free plasma VEGF and lower soluble VEGF receptor-1 in acute mountain sickness.

@article{Patot2005GreaterFP,
  title={Greater free plasma VEGF and lower soluble VEGF receptor-1 in acute mountain sickness.},
  author={Martha C. Tissot van Patot and Guy Leadbetter and Linda E. Keyes and Jamie Bendrick-Peart and Virginia E Beckey and Uwe Christians and Peter H Hackett},
  journal={Journal of applied physiology},
  year={2005},
  volume={98 5},
  pages={1626-9}
}
Vascular endothelial growth factor (VEGF) is a hypoxia-induced protein that produces vascular permeability, and limited evidence suggests a possible role for VEGF in the pathophysiology of acute mountain sickness (AMS) and/or high-altitude cerebral edema (HACE). Previous studies demonstrated that plasma VEGF alone does not correlate with AMS; however, soluble VEGF receptor (sFlt-1), not accounted for in previous studies, can bind VEGF in the circulation, reducing VEGF activity. In the present… CONTINUE READING