Greater bone formation of Y2 knockout mice is associated with increased osteoprogenitor numbers and altered Y1 receptor expression.

@article{Lundberg2007GreaterBF,
  title={Greater bone formation of Y2 knockout mice is associated with increased osteoprogenitor numbers and altered Y1 receptor expression.},
  author={Pernilla Lundberg and Susan J. Allison and Nicola J. Lee and P. A. J. Baldock and Nathalie Brouard and Stephanie Rost and Ronaldo F. Enriquez and Amanda Sainsbury and Meriem Lamghari and Paul Steven Simmons and John A. Eisman and Edith M. Gardiner and Herbert Herzog},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 26},
  pages={19082-91}
}
Germ line or hypothalamus-specific deletion of Y2 receptors in mice results in a doubling of trabecular bone volume. However, the specific mechanism by which deletion of Y2 receptors increases bone mass has not yet been identified. Here we show that cultured adherent bone marrow stromal cells from Y2(-/-) mice also demonstrate increased mineralization in vitro. Isolation of two populations of progenitor cell types, an immature mesenchymal stem cell population and a more highly differentiated… CONTINUE READING
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Greater Osteoprogenitor Number of Y2 Knockout Mice 19090 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

  • P. Lundberg, A. Lie, A. Bjurholm, P. P. Lehenkari, M. A. Horton, Lerner
  • U Q L irary on O cber 9,
  • 2007

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