Greater antitumor efficacy of paclitaxel administered before epirubicin in a mouse mammary carcinoma

  title={Greater antitumor efficacy of paclitaxel administered before epirubicin in a mouse mammary carcinoma},
  author={Anna Cividalli and Giorgio Cruciani and Esther Livdi and Eugenia Cordelli and Brighitta Eletti and Donatella Tirindelli Danesi},
  journal={Journal of Cancer Research and Clinical Oncology},
Combined treatment with paclitaxel and anthracyclines is increasingly being tested in clinical practice. Epirubicin is in general administered before paclitaxel. We have investigated, using a murine mammary adenocarcinoma, whether the efficacy and toxicity of this combination is influenced by treatment sequence, different time intervals and dose intensity. The tumor was transplanted into the right hind foot of C3D2F1 female mice. Paclitaxel was administered i.p. in doses ranging from 15 mg/kg… CONTINUE READING


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