Corpus ID: 10375717

Greater activation of smooth muscle alpha-2 adrenoceptors by epinephrine in distal than in proximal segments of rat tail artery.

@article{Rajanayagam1987GreaterAO,
  title={Greater activation of smooth muscle alpha-2 adrenoceptors by epinephrine in distal than in proximal segments of rat tail artery.},
  author={M. A. Rajanayagam and I. C. Medgett},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1987},
  volume={240 3},
  pages={
          989-97
        }
}
  • M. A. Rajanayagam, I. C. Medgett
  • Published 1987
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • The effects of selective blockade of alpha-1 and alpha-2 adrenoceptors on the vasoconstrictor responses to epinephrine (EPI) and norepinephrine (NOR) were compared in perfused/superfused proximal and distal segments of rat tail artery. The influence of neuronal uptake and of activation of beta adrenoceptors was also investigated. EPI was more potent in distal than in proximal segments. The antagonistic effect of idazoxan (100 nM) against EPI was greater in distal than in proximal segments… CONTINUE READING
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