Great times for small molecules: c-di-AMP, a second messenger candidate in Bacteria and Archaea.

@article{Rmling2008GreatTF,
  title={Great times for small molecules: c-di-AMP, a second messenger candidate in Bacteria and Archaea.},
  author={Ute R{\"o}mling},
  journal={Science signaling},
  year={2008},
  volume={1 33},
  pages={pe39}
}
Successful cell division in pro- and eukaryotes is ensured by checkpoints that regulate cell cycle progression. Structural and biochemical analyses of the DNA integrity scanning protein (DisA) have recently shown that its domain of unknown function, DUF147 [renamed DAC (for diadenylate cyclase)], has diadenylate cyclase activity. This diadenylate cyclase activity is abolished when DisA binds to branched DNA substrates, which arise during DNA double-strand breaks that can spontaneously occur… CONTINUE READING
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