Grb2/Ash binds directly to tyrosines 1068 and 1086 and indirectly to tyrosine 1148 of activated human epidermal growth factor receptors in intact cells.

@article{Okutani1994Grb2AshBD,
  title={Grb2/Ash binds directly to tyrosines 1068 and 1086 and indirectly to tyrosine 1148 of activated human epidermal growth factor receptors in intact cells.},
  author={Takenori Okutani and Yoshinori Okabayashi and Yoshiaki Kido and Yasuro Sugimoto and Kazushige Sakaguchi and Koozi Matuoka and Tadaomi Takenawa and Masato Kasuga},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 49},
  pages={
          31310-4
        }
}
The activation of receptor tyrosine kinases generates tyrosine-phosphorylated recognition motifs for the binding of signaling proteins containing Src homology 2 domains. We determined the binding sites of Grb2/Ash, an Src homology 2 domain-containing adaptor protein, within epidermal growth factor (EGF) receptors, using Chinese hamster ovary cells overexpressing human EGF receptor mutants in which one of the autophosphorylation sites was retained. In intact cells, the amount of Grb2/Ash… CONTINUE READING

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