Grb2, a simple adapter with complex roles in lymphocyte development, function, and signaling.

@article{Jang2009Grb2AS,
  title={Grb2, a simple adapter with complex roles in lymphocyte development, function, and signaling.},
  author={Ihn Kyung Jang and Jinping Zhang and Hua Gu},
  journal={Immunological reviews},
  year={2009},
  volume={232 1},
  pages={150-9}
}
Lymphocyte development, activation, and tolerance depend on antigen receptor signaling transduced via multiple intracellular signalosomes. These signalosomes are assembled by different adapters. Given that signaling molecules can be either positive or negative regulators for a biochemical target, the complex of a target with different regulator may dictate the final signaling outcome. Grb2 is a simple adapter known to be involved in a variety of growth factor receptor signaling. However, its… CONTINUE READING