Gray matter atrophy and freezing of gait in Parkinson's disease: Is the evidence black-on-white?

@article{Herman2014GrayMA,
  title={Gray matter atrophy and freezing of gait in Parkinson's disease: Is the evidence black-on-white?},
  author={Talia Herman and Keren Rosenberg-Katz and Yael Jacob and Nir Giladi and Jeffrey M. Hausdorff},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  year={2014},
  volume={29 1},
  pages={134-9}
}
OBJECTIVES The pathophysiology underlying freezing of gait (FOG) in Parkinson's disease (PD) is poorly understood. We tested whether gray matter (GM) atrophy contributes to FOG in PD. METHODS Voxel-based morphometry quantified GM atrophy in 106 patients who were classified as freezers (n = 30) or nonfreezers (n = 76). Well-matched smaller subgroups were also studied. Balance, gait, and cognitive function were assessed, and we evaluated the relationship between GM, FOG severity, and symptoms… CONTINUE READING

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