Graviola: a novel promising natural-derived drug that inhibits tumorigenicity and metastasis of pancreatic cancer cells in vitro and in vivo through altering cell metabolism.

@article{Torres2012GraviolaAN,
  title={Graviola: a novel promising natural-derived drug that inhibits tumorigenicity and metastasis of pancreatic cancer cells in vitro and in vivo through altering cell metabolism.},
  author={Maria Bella Palomo Torres and Satyanarayana Rachagani and Vinee Purohit and Poomy Pandey and Suhasini Joshi and Erik D. Moore and Sonny Johansson and Pankaj K Singh and Apar Kishor P. Ganti and Surinder Batra},
  journal={Cancer letters},
  year={2012},
  volume={323 1},
  pages={29-40}
}
Pancreatic tumors are resistant to conventional chemotherapies. The present study was aimed at evaluating the potential of a novel plant-derived product as a therapeutic agent for pancreatic cancer (PC). The effects of an extract from the tropical tree Annona Muricata, commonly known as Graviola, was evaluated for cytotoxicity, cell metabolism, cancer-associated protein/gene expression, tumorigenicity, and metastatic properties of PC cells. Our experiments revealed that Graviola induced… CONTINUE READING
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