Graves' hyperthyroidism and ophthalmopathy associated with pemphigus vulgaris: onset of thyroid autoimmune disease during chronic low-dose glucocorticoid therapy.

@article{Bartalena1997GravesHA,
  title={Graves' hyperthyroidism and ophthalmopathy associated with pemphigus vulgaris: onset of thyroid autoimmune disease during chronic low-dose glucocorticoid therapy.},
  author={Luigi Bartalena and Fausto Bogazzi and Luca Chiovato and Maria Laura Piera Tanda and E. C. Martino},
  journal={Journal of endocrinological investigation},
  year={1997},
  volume={20 3},
  pages={155-7}
}
A 38-year-old caucasian woman developed typical Graves' hyperthyroidism and ophthalmopathy while being chronically treated for pemphigus vulgaris with low doses of glucocorticoids capable of effectively controlling skin disease. HLA typing showed positivity for DR3 and DR4, suggesting a genetic susceptibility for both Graves' disease and pemphigus vulgaris. The apparent contradiction whereby thyroid autoimmune disease flared up during therapy with glucocorticoids, known for their… CONTINUE READING

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