Grass pollen immunotherapy for hayfever is associated with increases in local nasal but not peripheral Th1:Th2 cytokine ratios.

@article{Wachholz2002GrassPI,
  title={Grass pollen immunotherapy for hayfever is associated with increases in local nasal but not peripheral Th1:Th2 cytokine ratios.},
  author={Petra A. Wachholz and Kayhan T. Nouri-Aria and Duncan R Wilson and Samantha M. Walker and Adrienne Verhoef and Stephen John Till and Stephen R. Durham},
  journal={Immunology},
  year={2002},
  volume={105 1},
  pages={56-62}
}
Grass pollen immunotherapy is the only treatment for hayfever that is both effective and confers long-term benefit. Immunotherapy may act by altering the local nasal mucosal T helper type 2 (Th2) to type 1 (Th1) cytokine balance either by down-regulation and/or immune deviation of T-lymphocyte responses. There is controversy as to whether these changes are detectable in peripheral blood. We therefore examined both local nasal and peripheral T-cell responses to allergen exposure in the same… CONTINUE READING