Grasping at shadows: revealing the elusive nature of essential genes.

  title={Grasping at shadows: revealing the elusive nature of essential genes.},
  author={T. Msadek},
  journal={Journal of bacteriology},
  volume={191 15},
  • T. Msadek
  • Published 2009
  • Biology, Medicine
  • Journal of bacteriology
  • The conundrum of studying a gene that is essential for bacterial viability poses a nontrivial genetic challenge that has been met with mixed success using multiple strategies. Most of the time, cursory analyses merely report the inability to inactivate a gene of interest, hence suggesting it is vital for the cell. The identification of essential genes has long been a “holy grail” of bacterial genetics (16) and is receiving increasing attention in this age of “omics,” as these genes are often… CONTINUE READING
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