Graphiumins, new thiodiketopiperazines from the marine-derived fungus Graphium sp. OPMF00224

  title={Graphiumins, new thiodiketopiperazines from the marine-derived fungus Graphium sp. OPMF00224},
  author={T. Fukuda and Minori Shinkai and Eri Sasaki and K. Nagai and Yuko Kurihara and A. Kanamoto and H. Tomoda},
  journal={The Journal of Antibiotics},
  • T. Fukuda, Minori Shinkai, +4 authors H. Tomoda
  • Published 2015
  • Chemistry, Medicine
  • The Journal of Antibiotics
  • Eight new thiodiketopiperazines, designated as graphiumins A to H (1–8), were isolated along with bisdethiobis(methylthio)-deacetylaranotin (9) and bisdethiobis(methylthio)-deacetylapoaranotin (10) from the culture broth of the marine-derived fungus Graphium sp. OPMF00224. The structures of the graphiumins were elucidated based on spectroscopic analyses (1D and 2D NMR data, ROESY correlations and CD data) and chemical methods. The absolute configuration of the common (3S)-3-hydroxy-octanoyl… CONTINUE READING
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