Graphical assessment of consistency in treatment effect among countries in multi-regional clinical trials.

@article{Chen2013GraphicalAO,
  title={Graphical assessment of consistency in treatment effect among countries in multi-regional clinical trials.},
  author={Joshua Chen and Hao Zheng and Hui Quan and Gang Li and Paul D Gallo and Soo Peter Ouyang and Bruce Binkowitz and Naitee Ting and Yoko Tanaka and Xiaolong Luo and Ekopimo Okon Ibia},
  journal={Clinical trials},
  year={2013},
  volume={10 6},
  pages={
          842-51
        }
}
BACKGROUND One key objective of a multi-regional clinical trial (MRCT) is to use the trial results to 'bridge' from the global level to local region in support of local registrations. However, data from each individual country are typically limited and the large number of countries will increase the chance of false positive findings. PURPOSE Graphical tools to facilitate identification of potential outlying countries could be useful for country-level assessment. Existing methods such as… CONTINUE READING
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